Fabrication of a silver particle integrated silicone polymer covered metal stent against sludge and biofilm formation and stent induced tissue inflammation. To reduce tissue or tumor ingrowth, covered self-expandable metal stents (SEMSs) have been developed. The effectiveness of covered SEMSs may be attenuated by sludge or stone formation or by stent clogging due to the formation of biofilm on the covering membrane. In this study, we tested the hypothesis that a silicone membrane containing silver particles (Ag-P) would prevent sludge and biofilm formation on the covered SEMS.
Materials. Fabrication of an Ag-P-integrated silicone polymer-covered self-expandable metal stent. Ag-P with an average particle size of 250 nm (NP-S250) was purchased from NTbase Co. Ltd. (Seoul, Korea).
Published 14 October 2016 in the Scientific Reforts.